Supporting Natural Clearance: A Major Step Change in PFAS Reduction with Cambiotics

If you’ve been following the Relentless Health blog, you know we spend a lot of time discussing the widespread issue of per- and polyfluoroalkyl substances (PFAS). In past posts, we’ve covered everything from their hidden presence in tap water and food packaging to the alarming reality that "safe" chemical exposure limits are increasingly failing our health.

For years, the standard playbook for dealing with these “forever chemicals” has revolved around the first three of our 4 Ms of PFAS reduction: Measure (testing your blood levels), Mitigate (filtering your water, avoiding non-stick cookware), and Monitor (re-testing over time). However, because the exceptionally strong carbon-fluorine bonds in PFAS prevent them from breaking down naturally, there hasn’t been a practical way to achieve the holy grail of detoxification: active, biological removal.

Until now.

Today, we are thrilled to kick off our new PFAS Reduction Program, featuring a groundbreaking collaboration with Cambiotics, a pioneering biotechnology company spun out of the University of Cambridge. Together, we are introducing a true paradigm shift in how we manage environmental toxins in the human body.

Why 46& is a Game-Changer

Currently, an estimated 99% of people worldwide have detectable levels of PFAS in their bodies. Because humans lack a natural metabolic mechanism to break them down, these chemicals bioaccumulate over decades, raising the risk for numerous chronic health issues, ranging from immune suppression to accelerated biological aging.

Avoidance is critical, but it’s no longer enough. We need a way to clear the toxic burden we already carry. Cambiotics is changing how we approach environmental toxins by helping to support the gut’s natural capacity to sequester and eliminate unwanted compounds. Through cutting-edge precision probiotics, Cambiotics has developed 46&, a revolutionary dietary supplement designed to support the body’s natural excretion of forever chemicals.

The Science Behind 46&

The breakthrough technology driving 46& stems from pioneering research conducted at the MRC Toxicology Unit at the University of Cambridge by Cambiotics co-founders Dr. Anna Lindell and Professor Kiran Patil.

Their findings, recently published in Nature Microbiology, revealed something extraordinary: specific, non-GMO strains of human gut bacteria have a remarkable capacity to bioaccumulate PFAS.

Here is how the 46& treatment works:

1. The Recirculation Challenge: Typically, unwanted compounds like PFAS don't just exit the body on their own. Instead, they get caught in a continuous loop known as enterohepatic circulation, moving between the liver, intestine, and bloodstream. This cycle makes it incredibly difficult for the body to clear them naturally.
   
   
2. Bacteria in Action: This is where Cambiotics' precision probiotic strains step in. These specialized microbes go to work directly in the digestive tract. Rather than letting toxins continue to circulate, the bacterial strains actively bioaccumulate the unwanted compounds, safely trapping them within the bacterial cells themselves.
   
   
3. Interrupting Reabsorption & Supporting Elimination: By locking these compounds away inside the bacteria, 46& successfully helps reduce their reabsorption back into the body. This crucial step interrupts the internal recirculation loop and supports the gut's natural elimination processes, allowing your body to finally clear these unwanted compounds for good.

This is a monumental step change. For the first time, we can introduce targeted microbes that support the gut's natural elimination processes, helping to reduce the reabsorption of unwanted compounds.

Completing the 4 Ms: Maintain and Remove

Our new PFAS Reduction Program seamlessly integrates Relentless Health’s testing infrastructure with Cambiotics' 46& probiotic. This science-backed solution is preparing for commercial launch later this year.

By pairing our at-home PFAS Core Panel with the 46& supplement, you will finally be able to close the loop on your toxic exposure:

1. Measure: Understand your baseline. Testing your blood with Relentless Health reveals your unique, accumulated PFAS burden.
2. Mitigate: Make informed lifestyle changes to stem the flow of incoming toxins.
3. Maintain & Remove: Utilize Cambiotics’ 46& probiotics to actively draw down the accumulated chemical load in your tissues via the digestive system.
4. Monitor: Re-test periodically to verify that your biological intervention is working and your levels are safely dropping.

Take the First Step Today

While 46& prepares for its highly anticipated US launch, there is no better time to prepare your body. You can’t fix what you haven't measured, and understanding your baseline PFAS levels today is the essential first step to participating in active reduction tomorrow.

Order your at-home PFAS test today to find out where your levels stand, and join our waitlist for updates on the Relentless Health x Cambiotics PFAS Reduction Program.

Together, we are finally putting an end to “forever.”